Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 139, Issue 1, Pages 163-176Publisher
SPRINGER
DOI: 10.1007/s10549-013-2483-4
Keywords
Flavonoids; Lignans; Breast cancer; Hormone receptors; EPIC
Categories
Funding
- European Commission: Public Health and Consumer Protection Directorate
- Ligue contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid
- German Cancer Research Center (DKFZ)
- German Federal Ministry of Education and Research
- Danish Cancer Society: Health Research Fund (FIS) of the Spanish Ministry of Health [RTICC DR06/0020/0091]
- Catalan Institute of Oncology of Spain
- Cancer Research UK
- Medical Research Council, UK
- Hellenic Health Foundation, Greece
- Italian Association for Research on Cancer-AIRC-Milan, Italy
- Compagnia San Paolo, Italy
- Dutch Ministry of Public Health, Welfare and Sports
- Dutch Ministry of Health
- Dutch Prevention Funds
- LK Research Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane, Sweden
- Nordforsk-Centre of Excellence programme
- Fondo de Investigacion Sanitaria (FIS) from the Spanish Ministry of Science and Innovation [CD09/00133]
- regional government from Asturias
- regional government from Andalucia
- regional government from Murcia
- regional government from Navarra
- regional government from Basque Country
- Cancer Research UK [14136] Funding Source: researchfish
- Medical Research Council [G1000143, G0401527] Funding Source: researchfish
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Evidence on the association between dietary flavonoids and lignans and breast cancer (BC) risk is inconclusive, with the possible exception of isoflavones in Asian countries. Therefore, we investigated prospectively dietary total and subclasses of flavonoid and lignan intake and BC risk according to menopause and hormonal receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 334,850 women, mostly aged between 35 and 70 years from ten European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the US Department of Agriculture, the Phenol-Explorer and the UK Food Standards Agency databases. Cox regression models were used to analyse the association between dietary flavonoid/lignan intake and the risk of developing BC. During an average 11.5-year follow-up, 11,576 incident BC cases were identified. No association was observed between the intake of total flavonoids [hazard ratio comparing fifth to first quintile (HRQ5-Q1) 0.97, 95 % confidence interval (CI): 0.90-1.04; P trend = 0.591], isoflavones (HRQ5-Q1 1.00, 95 % CI: 0.91-1.10; P trend = 0.734), or total lignans (HRQ5-Q1 1.02, 95 % CI: 0.93-1.11; P trend = 0.469) and overall BC risk. The stratification of the results by menopausal status at recruitment or the differentiation of BC cases according to oestrogen and progesterone receptors did not affect the results. This study shows no associations between flavonoid and lignan intake and BC risk, overall or after taking into account menopausal status and BC hormone receptors.
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