Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 131, Issue 1, Pages 239-253Publisher
SPRINGER
DOI: 10.1007/s10549-011-1723-8
Keywords
Carotenoids; Breast cancer; Meta-analysis; Meta-regression
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The purpose of this article is to comprehensively summarize the associations between carotenoids and breast cancer and quantitatively estimate their dose-response relationships. We searched PubMed, Embase, and Cochrane databases (from January 1982 to 1 May 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of carotenoids. Two reviewers independently extracted data using a standardized form; with any discrepancy adjudicated by the third reviewer. 33 studies met the inclusion criteria. Comparing the highest with the lowest intake: dietary alpha-carotene intake significantly reduced the breast cancer risk by 9.0% (pooled RR = 0.91; 95% CI: 0.85-0.98; P = 0.01), dietary beta-carotene intake reduced the risk by 6.0% (pooled RR = 0.94; 95% CI: 0.88-1.00; P = 0.05); total beta-carotene intake reduced the risk by 5.0% (pooled RR = 0.95; 95% CI: 0.90-1.01; P = 0.08) when data from cohort studies were pooled. Significant dose-response relationships were observed in both the higher intake of dietary and total beta-carotene with reduced breast cancer risk when data from cohort studies (P (trend) < 0.01, P (trend) = 0.03) and case-control studies (P (trend) < 0.01, P (trend) < 0.01) were pooled, respectively. Dietary alpha-carotene intake could reduce the breast cancer risk. The relationships between dietary and total beta-carotene intake and breast cancer need to be confirmed. No significant association between dietary intake of beta-cryptoxanthin, lutein/+zeaxanthin, and lycopene and breast cancer was observed.
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