Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 128, Issue 1, Pages 7-21Publisher
SPRINGER
DOI: 10.1007/s10549-011-1499-x
Keywords
Cell adhesion molecules; Breast cancer; Metastasis
Categories
Funding
- National Natural Science Foundation of China [30872518]
- Major Program of Applied Basic Research Projects of Tianjin [09JCZDJC19800]
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Metastasis is responsible for the majority of breast cancer-related deaths. The metastatic spread of cancer cells is a complicated process that requires considerable flexibility in the adhesive properties of both tumor cells and other interacting cells. Cell adhesion molecules (CAMs) are membrane receptors that mediate cell-cell and cell-matrix interactions, and are essential for transducing intracellular signals responsible for adhesion, migration, invasion, angiogensis, and organ-specific metastasis. This review will discuss the recent advances in our understanding on the biological functions, signaling mechanisms, and therapeutic potentials of important CAMs involved in breast cancer metastasis.
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