Journal
TRANSCRIPTION-AUSTIN
Volume 1, Issue 3, Pages 149-153Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.1.3.13229
Keywords
alternative splicing; angiogenesis; cancer; Neuropilin-1; transcription; vascular endothelial growth factor
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Funding
- European Research Council (ERC) [20090506]
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The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.
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