Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 117, Issue 3, Pages 517-524Publisher
SPRINGER
DOI: 10.1007/s10549-008-0169-0
Keywords
ACI rat; Breast cancer etiology; Breast cancer prevention; Tamoxifen; Estrogen receptor; Rat model
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Funding
- NCI NIH HHS [R01 CA077876-06, R01 CA077876] Funding Source: Medline
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The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5-7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonance imaging, by 89%. Tumors expressed estrogen receptors (ER), progesterone receptor (PR), and Erbb2. ER alpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers.
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