3.8 Article

Coordination of glucose and glutamine utilization by an expanded Myc network

Journal

TRANSCRIPTION-AUSTIN
Volume 1, Issue 1, Pages 36-40

Publisher

TAYLOR & FRANCIS INC
DOI: 10.4161/trns.1.1.12142

Keywords

glucose; glutamine; nutrient; mitochondria; MondoA; Myc; TXNIP

Funding

  1. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM055668] Funding Source: NIH RePORTER
  2. NIGMS NIH HHS [R01 GM055668] Funding Source: Medline

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Glucose and glutamine are the most abundant circulating nutrients and support the growth and proliferation of all cells, in particular rapidly growing and dividing cancer cells. Several recent studies implicate an expanded Myc network in how cells sense and utilize both glucose and glutamine. These studies reveal an unappreciated coordination between glycolysis and glutaminolysis, potentially providing new targets for therapeutic intervention in cancer.

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