Journal
TRANSCRIPTION-AUSTIN
Volume 1, Issue 1, Pages 36-40Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.1.1.12142
Keywords
glucose; glutamine; nutrient; mitochondria; MondoA; Myc; TXNIP
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM055668] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM055668] Funding Source: Medline
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Glucose and glutamine are the most abundant circulating nutrients and support the growth and proliferation of all cells, in particular rapidly growing and dividing cancer cells. Several recent studies implicate an expanded Myc network in how cells sense and utilize both glucose and glutamine. These studies reveal an unappreciated coordination between glycolysis and glutaminolysis, potentially providing new targets for therapeutic intervention in cancer.
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