Journal
LOCAL AND REGIONAL ANESTHESIA
Volume 3, Issue -, Pages 93-100Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/LRA.S7977
Keywords
nanogels; nanoparticles; active drug compounds; local anesthetics; polymeric nanoparticles; procaine hydrochloride (PrHy)
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Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochloride (PrHy; a local anesthetic drug of the amino ester group) is described and discussed.
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