Journal
BRAIN STRUCTURE & FUNCTION
Volume 213, Issue 6, Pages 501-509Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-009-0203-y
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Funding
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Quebec
- Canadian Foundation for Innovation
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A common Single-Nucleotide Polymorphism in the Brain-Derived Neurotrophic Factor (BDNF) gene coding the Val66Met substitution in the pro-BDNF protein has been associated with a number of behavioural and neuroanatomical phenotypes; the latter include, for example, regional differences in volumes of the hippocampus and prefrontal grey matter. Here, we show that the observed regional differences may not stem from a localised effect of this gene. Our analysis of regional brain volume in a cohort of 331 adolescents indicates that the Val66Met substitution has a global effect on brain volume, and that the observed local differences are to be expected if brain allometry-the covariance pattern of regional brain volumes-is taken into account.
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