Journal
BRAIN STIMULATION
Volume 7, Issue 2, Pages 304-307Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2013.12.012
Keywords
Focused ultrasound; Cell proliferation; Neurogenesis; Astrogenesis; Hippocampus
Categories
Funding
- Government of Ontario
- Alzheimer Society of Canada
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes for Health Research [FRN 93603]
- National Institutes of Health [EB003268]
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Transcranial focused ultrasound (FUS) and microbubble contrast agent, applied at parameters known to transiently increase blood-brain barrier permeability, were tested for the potential to stimulate hippocampal neurogenesis. In adult mice, FUS treatment significantly increased the number of proliferating cells and newborn neurons in the dentate gyrus of the dorsal hippocampus. This provides evidence that FUS with microbubbles can stimulate hippocampal neurogenesis, a process involved in learning and memory and affected in neurological disorders, such as Alzheimer's disease. (C) 2014 Elsevier Inc. All rights reserved.
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