Journal
BRAIN STIMULATION
Volume 7, Issue 3, Pages 345-349Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2014.01.008
Keywords
Deep brain stimulation; Dystonia; Parkinson's disease
Categories
Funding
- United States National Institutes of Health/National Institutes of Neurological Disorders and Stroke [K23NS067053]
- Dystonia Center of Excellence Grant from the Bachmann Strauss Dystonia Coalition
Ask authors/readers for more resources
Background: Deep brain stimulation has become a routine therapy for movement disorders, but it is relatively invasive and costly. Although stimulation intensity relates to battery longevity, less is known about how diagnosis and stimulation target contribute to this clinical outcome. Here we evaluate battery longevity in movement disorders patients who were treated at a tertiary referral center. Objective: To compare single channel pulse generator longevity in patients with movement disorders. Methods: With Institutional Review Board approval, we evaluated 470 consecutive Soletra implants for routine care. Battery longevity was estimated with Kaplane-Meier analyses, and group comparisons were performed with the log rank mean test. The frequency of clinic encounters for ongoing care was evaluated across diagnoses with analysis of variance (ANOVA). Results: The mean pulse generator longevity was 44.9 +/- 1.4 months. Pallidal DBS for dystonia was associated with shorter battery longevity than subthalamic and thalamic DBS for Parkinson's disease and essential tremor (28.1 +/- 2.1 versus 47.1 +/- 1.8 and 47.8 +/- 2.6 months, respectively, mean +/- standard error, P < 0.001), and dystonia patients required more frequent clinic visits for routine care (F = 6.0, P = 0.003). Pallidal DBS for Parkinson's disease and thalamic DBS for cerebellar outflow tremor were associated with shorter battery longevity, as well (35.3 +/- 4.6 and 26.4 +/- 4.3 months, respectively). Conclusions: Pallidal DBS for dystonia was associated with shorter battery longevity and more frequent stimulator adjustments versus DBS for Parkinson's disease and essential tremor. Characteristics of the stimulation target and disease pathophysiology both likely contribute to battery longevity in patients with movement disorders. (C) 2014 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available