Journal
BRAIN RESEARCH REVIEWS
Volume 63, Issue 1-2, Pages 2-10Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainresrev.2009.12.001
Keywords
Astrocyte; Membrane current; Transmitter receptor; Gap junction; Morphology; Heterogeneity
Categories
Funding
- Deutsche Forschungsgemeinschaft [1172]
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Astrocytes as a cell population are not well defined and comprise a heterogeneous population of cells. There are at least 9 different morphological variants which can coexist within one given brain region. Human astrocytes have a considerably more complex morphology as their rodent counterparts. There are also a number of functional differences depending on brain region and developmental stage in the normal (not pathologic) brain. Astrocytes can differ in functional gap junctional coupling, expression of transmitter receptors, membrane currents, and glutamate transporters. We feel that astrocyte heterogeneity has not yet been thoroughly explored and what we report here will just be a beginning of a new field of research. (C) 2009 Elsevier B.V. All rights reserved.
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