Journal
BRAIN RESEARCH REVIEWS
Volume 60, Issue 1, Pages 114-124Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainresrev.2008.12.019
Keywords
Peroxisome proliferator-activated receptor; Rosiglitazone; Estrogen receptor; GPR30
Categories
Funding
- NIDA NIH HHS [K02 DA019656, DA19656] Funding Source: Medline
- NINDS NIH HHS [NS055835, NS62306, R01 NS062306, R01 NS055835] Funding Source: Medline
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We discuss and present new data regarding the physiological and molecular mechanisms of nuclear receptor activation in pain control, with a particular emphasis on non-genomic effects of ligands at peroxisome proliferator-activated receptor (PPAR), GPR30, and classical estrogen receptors. PPAR alpha agonists rapidly reduce both acute and chronic pain in a number of pain assays. These effects precede transcriptional anti-inflammatory actions, and are mediated in part by IKca and BKca channels on DRG neurons. In contrast to the peripheral site of action of PPAR alpha ligands, the dorsal horn supports the expression of PPAR gamma. Intrathecal administration of PPAR gamma ligands rapidly (<= 5 min) attenuated mechanical and thermal hypersensitivity associated with nerve injury in a dose-dependent manner that could be blocked with PPAR gamma antagonists. By contrast, a PPAR gamma antagonist itself rapidly increased the mechanical allodynia associated with nerve injury. These data suggest that ligand-dependent, non-genomic activation of spinal PPAR gamma decreases behavioral signs of inflammatory and neuropathic pain. We also report that the GPR30 is expressed on cultured sensory neurons, that activation of the receptor elicits signaling to increase calcium accumulation. This signaling may contribute to increased neuronal sensitivity as treatment with the GPR30 agonist induces hyperalgesia. Finally, application of the membrane-impermeable 17 beta-E-2-BSA rapidly (within 15 min) enhanced BK-stimulated inositol phosphate (IP) accumulation and PGE(2)-mediated cAMP accumulation in trigeminal ganglion cultures. We conclude that nuclear receptor ligands may operate through rapid, non-genomic mechanisms to modulate inflammatory and neuropathic pain. (C) 2008 Elsevier B.V. All rights reserved.
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