Journal
BRAIN RESEARCH REVIEWS
Volume 59, Issue 1, Pages 22-33Publisher
ELSEVIER
DOI: 10.1016/j.brainresrev.2008.04.007
Keywords
Erythropoietin; Hypoxia; Ischemia; Mechanism; Neuroprotection; Review
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Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral hypoxia and ischemia have been shown to attenuate by EPO treatment. After binding to the EPO receptor, EPO is capable of initiating a cascade of events which -via different pathways-may lead to neuroprotection. The circumstances that determine which specific signalling route(s) are activated by EPO are largely unknown. We aim to provide the reader with a timely overview on the use of EPO in models of stroke and hypoxia-ischemia and to discuss the molecular events that underlie its neuroprotection. (C) 2008 Elsevier B.V. All rights reserved.
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