Journal
BRAIN RESEARCH REVIEWS
Volume 58, Issue 1, Pages 121-135Publisher
ELSEVIER
DOI: 10.1016/j.brainresrev.2007.12.003
Keywords
sign-tracking; Pavlovian; autoshaping; drug abuse; addiction; salience
Categories
Funding
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA008499, R21AA012023] Funding Source: NIH RePORTER
- NIAAA NIH HHS [R01 AA008499-02, R21 AA012023-01A1] Funding Source: Medline
- PHS HHS [R01 AAA-10124-03, R21 AAA-12023-02] Funding Source: Medline
Ask authors/readers for more resources
Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian sign-tracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Sign-tracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered. (C) 2007 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available