Journal
BRAIN RESEARCH REVIEWS
Volume 57, Issue 1, Pages 22-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainresrev.2007.06.015
Keywords
feedback; locomotion; reticulospinal; rhythm generation; synapses; xenopus
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Funding
- Wellcome Trust Funding Source: Medline
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A long-standing hypotheses is that locomotion is turned on by descending excitatory synaptic drive. in young frog tadpoles, we show that prolonged swimming in response to a brief stimulus can be generated by a small region of caudal hindbrain and rostral spinal cord. Whole-cell patch recordings in this region identify hindbrain neurons that excite spinal neurons to drive swimming. Some of these hindbrain reticulospinal neurons excite each other. We consider how feedback excitation within the hindbrain may provide a mechanism to drive spinal locomotor networks. (c) 2007 Elsevier B.V. All rights reserved.
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