Journal
BRAIN RESEARCH REVIEWS
Volume 58, Issue 1, Pages 160-170Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainresrev.2008.01.004
Keywords
ghrelin; food intake; reward; energy; brain
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Funding
- NIDA NIH HHS [R01 DA021280-02, R01 DA021280] Funding Source: Medline
- NIDDK NIH HHS [P30 DK050456-13, P30 DK050456] Funding Source: Medline
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Ghrelin, the endogenous agonist of the growth hormone secretagogue receptor, has been shown to induce robust feeding responses in numerous experimental models. Although ghrelin comes from both peripheral and central sources, its hyperphagic properties, to a large extent, arise from activity at the brain level. The current review focuses on describing central mechanisms through which this peptide affects consumption. We address the issue of whether ghrelin serves just as a signal of energy needs of the organism or - as suggested by the most recent findings - also affects food intake via other feeding-related mechanisms, including reward and memory. Complexity of ghrelin's role in the regulation of ingestive behavior is discussed by characterizing its influence on consumption, reward and memory as well as by defining its function within the brain circuitry and interplay with other neuropeptides. (C) 2008 Elsevier B.V. All rights reserved.
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