Journal
BRAIN RESEARCH BULLETIN
Volume 105, Issue -, Pages 36-45Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2013.09.005
Keywords
Protein kinase Mzeta; PKM; ZIP; Memory maintenance; Epigenetics; Restabilization
Categories
Funding
- NIMH NIH HHS [R03 MH090426, R01 MH069558] Funding Source: Medline
Ask authors/readers for more resources
Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKM zeta) in maintaining established memory. PKM zeta, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during memory formation in order to preserve the memory engram over time. Initial studies investigating the role of PKM zeta were largely successful in demonstrating a role for the kinase in memory maintenance; disrupting PKM zeta activity with zeta-inhibitory peptide (ZIP) was successful in disrupting a variety of established associations in a number of key brain regions. More recent work, however, has questioned both the role of PKM zeta in memory maintenance and the effectiveness of ZIP as a specific inhibitor of PKM zeta activity. Here, we outline the research both for and against the idea that PKM zeta is a memory maintenance mechanism and discuss how these two lines of research can be reconciled. We conclude by proposing a number of studies that would help to clarify the role of PKM zeta in memory and define other mechanisms the brain may use to maintain memory. (C) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available