Journal
BRAIN RESEARCH BULLETIN
Volume 99, Issue -, Pages 95-99Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2013.10.006
Keywords
D-Cycloserine; NMDA receptor; Sociability; Social preference; Balb/c mouse
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Funding
- Eastern Virginia Medical School
- Commonwealth Health Research Board of the Commonwealth of Virginia
- Office of the Dean of Eastern Virginia Medical School
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The genetically inbred Balb/cJ (Balb/c) mouse with functional alteration of its endogenous tone of NMDA receptor-mediated neurotransmission displays impaired sociability in a standard paradigm; this mouse strain has been proposed as a model of autism spectrum disorders (ASDs). Prior work showed that treatment of the Balb/c mouse with a centrally effective dose of D-cycloserine, a partial glycine(B) NMDA receptor agonist, improved several measures of its sociability. Additionally, D-cycloserine-treated Balb/c mice show greater preference for a social stimulus mouse than an inanimate object. We wondered if treatment with D-cycloserine also improved the social salience of the Balb/c mouse for normally sociable comparator strains. The current experiments explored whether C578I/6J (B6) and ICR mouse strains prefer D-cycloserine-treated to vehicle-treated Balb/c stimulus mice in a paradigm that evaluated social preference. The results showed that B6 mice prefer D-cycloserine-treated Balb/c mice to vehicle-treated Balb/c mice, suggesting that treatment could have resulted in normalization of emitted social cues. (C) 2013 Elsevier Inc. All rights reserved.
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