Journal
BRAIN RESEARCH BULLETIN
Volume 84, Issue 2, Pages 163-168Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2010.11.015
Keywords
Salvianolic acid B; Traumatic brain injury; Neuroprotection; Cytokines; Anti-inflammation
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Funding
- National Natural Science Foundation of China [30670796, 30930093]
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Salvianolic acid B (SalB), a bioactive compound isolated from the Chinese medicinal herb Danshen, has been shown to exert various anti-oxidative and anti-inflammatory activities in in vitro and in vivo studies. Here, we investigated the protective effects of SalB on traumatic brain injury (TBI) in mice. When administered within 2 h after TBI onset, SalB (25 mg/kg) reduced brain edema, lesion volume and motor functional deficits, and improved spatial learning and memory abilities. Moreover, SalB treatment inhibited the neutrophil infiltration and microglial activation at 48 h after TBI. Enzyme-linked immunosorbent assay (ELISA) for brain tissue homogenates was performed at 24 h after TBI to evaluate the expression of inflammation-related cytokines. The results showed that SalB suppressed the expression of pro-inflammatory cytokines TNE-alpha and IL-1 beta, whereas enhanced the expression of anti-inflammatory cytokines IL-10 and TGF-beta 1. All of these findings extended the protective role of SalB in the model of TBI and suggested that these protective effects might be associated with its anti-inflammatory activities. Thus SalB may have therapeutic potential for patients with TBI and perhaps other forms of acute brain injury. (C) 2010 Elsevier Inc. All rights reserved.
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