Journal
BRAIN RESEARCH BULLETIN
Volume 84, Issue 6, Pages 419-424Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2011.01.011
Keywords
P2X(3) receptor; Oxymatrine; SCG; DRG; Myocardial ischemic injury
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Funding
- National Natural Science Foundation of China [31060139, 30860086, 30860333, 30660048, 30460040]
- Ministry of Education of China [20070403007]
- Technology Pedestal and Society Development Project of Jiangxi Province [2010BSA09500]
- Natural Science Foundation of Jiangxi Province [0640042, 2008GZY0029]
- Educational Department of Jiangxi Province [2007-60, GJJ08049]
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Sympathoexcitatory reflex is characterized by an increase in blood pressure and sympathetic nerve activity. P2X(3) receptors in SCG neurons are involved in increasing sympathoexcitatory reflex after myocardial ischemic (MI) injury. The present study is aimed to explore the effects of oxymatrine (Oxy) on the transmission of myocardial ischemic signaling mediated by P2X(3) receptors in rat superior cervical ganglia (SCG) and cervical dorsal root ganglia (DRG) in the sympathoexcitatory reflex after myocardial ischemic injury. In this study, the expression levels of P2X(3) immunoreactivity, mRNA and protein were analyzed in SCG and DRG neurons by immunohistochemistry, in situ hybridization and Western blotting. The results show that the myocardial ischemic injury induce:; the increase of the systolic blood pressure and heart rate and upregulates the expression of P2X(3) receptors in SCG and DRG neurons. Upregulated expression of P2X(3) receptors in SCG and DRG neurons subsequently leads to the aggravated sympathoexcitatory reflex. Oxymatrine reduces the systolic blood pressure and heart rate in myocardial ischemic rats. After myocardial ischemic rats are treated with oxymatrine, the expression levels of P2X(3) immunoreactivity, mRNA and protein are lower than those in myocardial ischemic rats. Oxymatrine may decrease the expression of P2X(3) receptor and depress the aggravated sympathoexcitatory reflex induced by the nociceptive transmission of myocardial ischemic injury via P2X(3) receptors of rat SCG and DRG neurons. (C) 2011 Elsevier Inc. All rights reserved.
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