Journal
BRAIN RESEARCH BULLETIN
Volume 84, Issue 2, Pages 137-143Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2010.12.009
Keywords
Metaplasticity; Hippocampus; NR2B subunit; NMDA receptor; Long-term potentiation
Categories
Funding
- Shanghai Pujiang Program [06PJ14053]
- Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry
- Shanghai Leading Academic Discipline Project [B205]
Ask authors/readers for more resources
The potential to exhibit synaptic plasticity itself is modulated by previous synaptic activity, which has been termed as metaplasticity. In this paper, we demonstrated that the activation of N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) subunit in NNDA receptors was required for hippocampal metaplasticity at Schaffer collateral-commissural fiber-CA1 synapses. Brief 5 Hz priming stimulation did not cause long-term synaptic plasticity; however, it could result in the inhibition of subsequently evoked long-term potentiation (LTP). Meanwhile, the application of selective antagonists for NR2B subunit of NMDA receptors after delivering priming stimulation could block the metaplasticity. In contrast, LTP induction was not affected by NR2B antagonists in slices without pre-treatment of priming stimulation. These results indicated that the activation of NR2B-containing NMDA receptors was required for metaplasticity. (C) 2010 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available