Journal
BRAIN RESEARCH BULLETIN
Volume 85, Issue 6, Pages 313-320Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2011.05.004
Keywords
Traumatic brain injury; Postsynaptic density; Glutamate receptor; Homer protein; Shank protein
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Funding
- National Natural Science Foundation of China [30670796, 30930093]
- 863 High-Tech Project [2009AA02Z419]
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Traumatic brain injury (TBI) is the major cause of death and disability, and the incidence of TBI continues to increase rapidly. In recent years, increasing attention has been paid to an important structure at the postsynaptic membrane: the postsynaptic density (PSD). Glutamate receptors, as major components of the PSD, are highly responsive to alterations in the glutamate concentration at excitatory synapses and activate intracellular signal transduction via calcium and other second messengers following TBI. PSD scaffold proteins (P50-95, Homer, and Shank), which anchor glutamate receptors and form a network structure, also have potential effects on these downstream signaling pathways. The changes in the function and structure of these major PSD proteins are also induced by TBI, indicating that there is a more complicated mechanism associated with PSD proteins in the pathophysiological process of TBI. (C) 2011 Elsevier Inc. All rights reserved.
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