Journal
BRAIN RESEARCH BULLETIN
Volume 81, Issue 1, Pages 33-37Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2009.10.003
Keywords
Morris water maze; Amygdaloid body; Memory; Ghrelin
Categories
Funding
- Hungarian Academy of Sciences [NKTH-OTKA K 68431, RET-008/2005, ETT 317/2006, ETT 315/2006]
- Pecs University Medical School
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According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male Wistar rats effects of bilateral intraamygdaloid microinfusion of 50 ng, 100 ng A-Ghr, 15 ng Ghr receptor antagonist D-Lys3-GHRP-6 (ANT) or ANT + 50 ng A-Ghr [dissolved in 0.15 M sterile saline], or vehicle in 0.4 mu l volume were investigated in Morris water maze paradigm. 50 ng A-Ghr significantly reduced latency to find the platform located in one of the quadrants of the maze. Effect of 50 ng A-Ghr was blocked by ANT pretreatment. ANT alone had no effect. Our results show that place learning linked memory processes are facilitated by A-Ghr in the rat ABL. It is a specific effect, because it could be eliminated by ANT pretreatment. (C) 2009 Elsevier Inc. All rights reserved.
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