Journal
BRAIN RESEARCH BULLETIN
Volume 81, Issue 4-5, Pages 491-496Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2009.09.008
Keywords
Harmine; BDNF; Chronic mild stress; Anhedonic behavior; Depression
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico' (CNPq-Brazil)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Instituto Cerebro e Mente
- UNESC
- THC-Pharm (Frankfurt, Germany)
- STI-Pharm (UK)
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The chronic mild stress (CMS) model has been used as an animal model of depression which induces anhedonic behavior in rodents. The present study was aimed to evaluate the behavioral and physiological effects of administration of P-carboline harmine in rats exposed to CMS Procedure. To this aim, after 40 days of exposure to CMS procedure, rats were treated with harmine (15 mg/kg/day) for 7 days. In this study, sweet food consumption, adrenal gland weight, adrenocorticotrophin hormone (ACTH) levels, and hippocampal brain-derived-neurotrophic factor (BDNF) protein levels were assessed. Our findings demonstrated that chronic stressful situations induced anhedonia, hypertrophy of adrenal gland weight, increase ACTH circulating levels in rats and increase BDNF protein levels. Interestingly, treatment with harmine reversed anhedonia, the increase of adrenal gland weight, normalized ACTH circulating levels and BDNF protein levels. Finally, these findings further support the hypothesis that harmine could be a new pharmacological tool for the treatment of depression. (C) 2009 Elsevier Inc. All rights reserved.
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