Journal
BRAIN RESEARCH BULLETIN
Volume 78, Issue 4-5, Pages 139-144Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2008.11.011
Keywords
The distal cerebrospinal fluid-contacting neurons; Spinal trigeminal nucleus; Substance P, immunohistochemistry; The orofacial formalin test, inflammatory pain
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Funding
- National Natural Science Foundation of China [30570974]
- Natural Science Foundation of Jiangsu Province [BK2004028]
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The distal cerebrospinal fluid-contacting neuron (dCSF-CN) is a peculiar type of neuron whose body is in the parenchyma of the brain and processes extend into cerebrospinal fluid (CSF) in the cavity of the ventricle in the central nervous system. Because most of the dCSF-CNs are found in the dorsal raphe nucleus (DR) of the brainstem, we presume these neurons relate to pain modulation. Many experiments have demonstrated that substance P (SP) plays an important role in the development of pain and hyperalgesia. To explore whether the dCSF-CNs modulated the orofacial inflammatory pain in rats, we examined behavioral changes with the orofacial formalin test and SP-expression in the dCSF-CNs and spinal trigeminal nucleus (STN) with dual immunohistochemical labeling for light microscopy or immunoelectron microscopy. It is revealed that 2 h after 2.5% formalin injection SP-expression in the dCSF-CNs and STN is upregulated significantly, which may be considered an important role for nociceptive processing. (C) 2008 Elsevier Inc. All rights reserved.
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