Journal
BRAIN RESEARCH
Volume 1573, Issue -, Pages 44-53Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2014.05.019
Keywords
Angiotensin-(1-7); Chronic cerebral hypoperfusion; Hippocampus; Nitric oxide; Neuronal loss; Astrocyte proliferation
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Funding
- Medical Science and Technology Development Foundation
- Nanjing Department of Health [ZKX 08035, YKK11031]
- Nanjing Bureau of Science and Technology [201104009]
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Chronic cerebral hypoperfusion (CCH) is associated with cognitive decline in aging, vascular dementia and Alzheimer's disease. Recently, angiotensin-(1-7) (Ang-(1-7)), one of the physiological constituents of the brain, was found to protect against cognitive dysfunction and brain ischemia. However, the effects of Ang-(1-7) on CCH-induced cognitive deficits remained unknown. In the present study, Ang-(1-7) significantly alleviated CCH-induced cognitive deficits in rats subjected to permanent bilateral occlusion of the common carotid arteries (a model of CCH). This neuroprotective effect was associated with increased nitric oxide generation, attenuated neuronal loss and suppressed astrocyte proliferation in the hippocampus. These findings demonstrate that Ang-(1-7) is a promising therapeutic agent for CCH-induced cognitive deficits. (C) 2014 Elsevier B.V. All rights reserved.
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