Journal
BRAIN RESEARCH
Volume 1515, Issue -, Pages 19-28Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2013.03.048
Keywords
Rat; Early-life-permethrin-treatment; Brain; Nurr1; NF-kB; Nrf-2
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Funding
- MIUR, National Grant [2008ZW3FJ3]
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Pesticide exposure during brain development represents an important risk factor for the onset of brain-aging processes. Here, the impact of permethrin administered to rats from 6th to 21st day of life, at a dose near to no observed adverse effect level (NOAEL), was studied when animals reached 500 day-old. The permethrin treatment induced a decrease in Nurr1 gene expression in striatum, an increase in hippocampus and cerebellum, while the protein level changed only in striatum where it was increased. NF-kB p65 gene expression was increased in cerebellum, while its protein level augmented in cerebellum and in prefrontal cortex and decreased in hippocampus of treated rats compared to control ones. Nrf-2 gene expression resulted significantly higher only in cerebellum of treated animals. The results suggest that early life permethrin treatment induces long-lasting effects leading to dopaminergic neuronal disorders, monitored by Nurr1 alteration. Moreover the impairment of NF-kB and Nrf-2, important for the balance between pro- and antiinflammatory systems, confirms that the neonatal permethrin treatment can influence genes involved with the onset of brain-ageing processes. (C) 2013 Elsevier B.V. All rights reserved.
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