Journal
BRAIN RESEARCH
Volume 1530, Issue -, Pages 82-105Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2013.07.014
Keywords
Progesterone; Traumatic brain injury; Neuroprotection
Categories
Funding
- NINDS NIH HHS [U01 NS062778] Funding Source: Medline
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The sex hormone progesterone has been shown to improve outcomes in animal models of a number of neurologic diseases, including traumatic brain injury, ischemia, spinal cord injury, peripheral nerve injury, demyelinating disease, neuromuscular disorders, and seizures. Evidence suggests it exerts its neuroprotective effects through several pathways, including reducing edema, improving neuronal survival, and modulating inflammation and apoptosis. In this review, we summarize the functional outcomes and pathophysiologic mechanisms attributed to progesterone treatment in neurologic disease. We then comment on the breadth of evidence for the use of progesterone in each neurologic disease family. Finally, we provide support for further human studies using progesterone to treat several neurologic diseases. (C) 2013 Elsevier B.V. All rights reserved.
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