Journal
BRAIN RESEARCH
Volume 1514, Issue -, Pages 123-127Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2013.02.013
Keywords
Phytoestrogens; Genistein; Daidzein; Cognition; Gender
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Funding
- NIA NIH HHS [P01 AG022550, R01 AG027353, P01 AG027956] Funding Source: Medline
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Phytoestrogens are plant-derived compounds found mainly in soy with known estrogenic properties and a potential for benefits to human health. Increased intake in phytoestrogens stemmed from the search for safe alternatives to hormone replacement therapies. Based on epidemiologic evidence comparing Western and Asian populations and clinical studies, phytoestrogens show promise to improve health and brain function. This review is focused on the effects of phytoestrogens on cognition by examining clinical and animal studies, with special attention placed on (1) a window of therapeutic opportunity which may explain the discrepancy among studies, and (2) whether a sex/gender difference exists in response to phytoestrogen intake and what the possible underlying mechanisms may be. Published by Elsevier B.V.
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