Journal
BRAIN RESEARCH
Volume 1492, Issue -, Pages 140-147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2012.11.023
Keywords
Cerebral hemorrhage; Minimally invasive procedure; Glutamate; Blood brain barrier; Neurological deficit score
Categories
Funding
- Guizhou Science and Technology Fund
Ask authors/readers for more resources
Introduction: To observe the effects of performing a minimally invasive procedure at different stages after intracerebral hemorrhage (ICH) on perihematomal glutamate level and neurological function. Methods: Forty-eight rabbits were randomly placed into a model control group (MC group, 24 rabbits) or a minimally invasive group (MI group, 24 rabbits). An ICH model was established in all of the animals. In the MI group, the ICH was evacuated by minimally invasive procedures in 6 h (6 rabbits), 12 h (6 rabbits), 18 h (6 rabbits) and 24 h (6 rabbits) after the ICH model was successfully induced. All of the animals were sacrificed within 48 h after the hematoma was evacuated by surgery. A neurological deficit score was determined, and the perihematomal glutamate level and the BBB permeability were measured. Results: The neurological deficit score, perihematomal glutamate level and BBB permeability of the MI group were decreased significantly compared with the MC group. Performing the minimally invasive procedures in 6-12 h after ICH showed the most significant decreases of the glutamate level, BBB permeability and neurological deficit score. Conclusions: The optimal time window of performing the minimally invasive procedures for the intracerebral hematoma evacuation might be within 6-12 h after hemorrhage. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available