Journal
BRAIN RESEARCH
Volume 1441, Issue -, Pages 64-78Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2011.12.063
Keywords
Alzheimer's disease; Diabetes; Cerebral glucose metabolism; Insulin signaling; Mitochondria; Oxidative stress
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Funding
- Fundacao para a Ciencia e a Tecnologia [SFRH/BD/40702/2007]
- Fundo Europeu de Desenvolvimento Regional [PTDC/SAU-NEU/103325/2008, PTDC/SAU-NMC/110990/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/40702/2007] Funding Source: FCT
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Many epidemiological studies have shown that diabetes, particularly type 2 diabetes, significantly increases the risk to develop Alzheimer's disease. Both diseases share several common abnormalities including impaired glucose metabolism, increased oxidative stress, insulin resistance and deposition of amyloidogenic proteins. It has been suggested that these two diseases disrupt common cellular and molecular pathways and each disease potentiates the progression of the other. This review discusses clinical and biochemical features shared by Alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies. (C) 2012 Elsevier B.V. All rights reserved.
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