Journal
BRAIN RESEARCH
Volume 1478, Issue -, Pages 64-73Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2012.08.025
Keywords
Coenzyme Q10; Hypoxia; Neural stem cells; Neuroprotection
Categories
Funding
- Korea Science and Engineering Foundation
- Ministry of Education, Science and Technology [2007-04717]
- Ministry for Health, Welfare & Family Affairs, Republic of Korea [A101712]
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Recanalization and secondary prevention are the main therapeutic strategies for acute ischemic stroke. Neuroprotective therapies have also been investigated despite unsuccessful clinical results. Coenzyme Q10 (CoQ10), which is an essential cofactor for electron transport in mitochondria, is known to have an antioxidant effect. We investigated the protective effects of CoQ10 against hypoxia in neural stem cells (NSCs). We measured cell viability and levels of intracellular signaling proteins after treatment with several concentrations of CoQ10 under hypoxia-reperfusion. CoQ10 protected NSCs against hypoxia-reperfusion in a concentration-dependent manner by reducing growth inhibition and inhibiting free radical formation. It increased the expression of a number of survival-related proteins such as phosphorylated Akt (pAkt), phosphorylated glycogen synthase kinase 3-beta (pGSK3-beta), and B-cell lymphoma 2 (Bcl-2) in NSCs injured by hypoxia-reperfusion and reduced the expression of death-related proteins such as cleaved caspase-3. We conclude that CoQ10 has effects against hypoxia-reperfusion induced damage to NSCs by enhancing survival signals and decreasing death signals. (C) 2012 Elsevier B.V. All rights reserved.
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