Journal
BRAIN RESEARCH
Volume 1483, Issue -, Pages 112-117Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2012.09.022
Keywords
Amyotrophic lateral sclerosis; Superoxide dismutase 1; SIRT1; Resveratrol; Heat shock protein; Heat shock factor 1
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Funding
- National Research Foundation of Korea [2009-0068713, 2009-0075097]
- National Research Foundation of Korea [2009-0068713, 2009-0075097] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps. (C) 2012 Elsevier B.V. All rights reserved.
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