Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 19, Pages 9825-9828Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b02194
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Funding
- 973 Program [2013CB933800]
- National Natural Science Foundation of China [21535004, 21227005, 21390411, 21305080]
- Natural Science Foundation of Shandong Province of China [ZR2015JL008, ZR2013BQ005]
- Program for Changjiang Scholars and Innovative Research Team in University
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Hydrogen peroxide (H2O2) as a reactive oxygen species (ROS) plays a crucial role in oxidative stress and signal transduction of organisms. Currently, a fluorescence probe has proven to be a powerful tool for the H2O2 analysis. However, the common problem is the slow response, causing difficulty in tracking H2O2 in situ. Herein, we describe a novel aggregation-induced emission (ATE) fluorescence probe based on increased polarity of C-B bonds that is well suited for monitoring H2O2 rapidly and selectively. Importantly, the probe was successfully applied to visualize H2O2 levels in living cells, which provides a rapid-response and highly selective fluorescence tool for monitoring of the H2O2 levels in biological process.
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