Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 8, Pages 4448-4454Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b00337
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Funding
- National Key Scientific Program of China [2011CB911000]
- National Key Basic Research Program of China [2013CB932702]
- NSFC [21325520, 21405100, 21405041, 21327009, 51302117, J1210040, 21177036]
- Foundation for Innovative Research Groups of NSFC [21221003]
- National Instrumentation Program [2011YQ030124]
- Hunan Provincial Natural Science Foundation [11JJ1002]
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Many one-photon fluorescence-based theranostic nanosystems have been developed for simultaneous therapeutic intervention/monitoring for various types of cancers. However, for early diagnosis of cancer, two-photon fluorescence microscopy (TPFM) can realize deep-tissue imaging with higher spatial resolution. In this study, we first report a multiple functional nanoprobe for contrast-enhanced bimodal cellular imaging and targeted therapy. Components of the nanoprobe include (1) two-photon dye-doped mesoporous silica nanoparticles (TPD-MSNs); (2) MnO2 nanosheets that act as a (i) gatekeeper for TPD-MSNs, (ii) quencher for TP fluorescence, and (iii) contrast agent for MRI; (3) cancer cell-targeting aptamers. Guided by aptamers, TPD-MSNs are rapidly internalized into the target cells. Next, intracellular glutathione reduces MnO2 to Mn2+ ions, resulting in contrast-enhanced TP fluorescence and magnetic resonance signal for cellular imaging. Meanwhile, preloaded doxorubicin and Chlorin e6 are released for chemotherapy and photodynamic therapy, respectively, with a synergistic effect and significantly enhanced therapeutic efficacy.
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