Journal
BRAIN RESEARCH
Volume 1386, Issue -, Pages 35-40Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2011.02.053
Keywords
Neuroblastoma; Cell morphology; Scanning ion conductance microscopy; Scanning probe microscopy
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Funding
- National Natural Science Foundation of China [30971184]
- Tianjin Natural Science Foundation of China [08JCYBJC26500]
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It is well known that heterogeneous neuroblastoma (NB) has three different phenotypic variants; the differentiation and transdifferentiation among them increase the complexity of this cancer. However, high-resolution characterization of their morphology has not been addressed by conventional microscopy. Under the help of high-resolution hopping probe ion conductance microscopy, we demonstrated that three morphologically distinct cell populations exist in live NB SK-N-SH cell line. Among these three types cells, N-type cells had the smallest cell volume and the biggest height, S-type owned the biggest cell volume and the smallest height, and I-type was intermediate between N- and S-type. The difference of microvilli morphology rendered I- and N-type cells with a higher RMS than S-type cells. These high-resolution morphologic criteria can provide more direct information to distinguish (Efferent cell types in NB tumor, and may give a hand to the development of new therapies and diagnosis. (C) 2011 Elsevier B.V. All rights reserved.
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