Journal
BRAIN RESEARCH
Volume 1317, Issue -, Pages 24-32Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2009.12.035
Keywords
Orexin; Hypocretin; Morphine; Opiate; Cocaine; Sensitization; Conditioned place preference
Categories
Funding
- National Institutes of Health [R01DA017676, F32DA023739, AA017537]
- State of Connecticut Department of Mental Health and Addiction Services
- Research Consortium on Stress, Self-control and Addiction [UL1-DE19586]
Ask authors/readers for more resources
Orexin (or hypocretin) has been implicated in mediating drug addiction and reward. Here, we investigated orexin's contribution to morphine-induced behavioral sensitization and place preference. Orexin-/- (OKO) mice and littermate wild-type (WT) controls (n = 56) and C57BL/6J mice (n = 67) were tested for chronic morphine-induced locomotor sensitization or for conditioned place preference (CPP) for a morphine- or a cocaine-paired environment. C57BL/6J mice received the orexin receptor 1 (Ox1r) antagonist, SB-334867, prior to test sessions. OKO mice did not significantly differ from WT controls in locomotor activity following acute- or chronic-morphine treatments. Similarly, mice treated with the Ox1r antagonist did not differ from vehicle controls in locomotor activity following acute- or chronic-morphine treatments. In contrast, while OKO mice did not differ from WT controls in preference for a morphine-paired environment, the Ox1r antagonist significantly attenuated place preference for a morphine-, but not a cocaine-paired, environment. These data suggest that orexin action is not required for locomotor responses to acute and chronic morphine, but Ox1r signaling can influence morphine-seeking in WT animals. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available