Journal
BRAIN RESEARCH
Volume 1348, Issue -, Pages 222-225Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2010.06.017
Keywords
Transthyretin (TTR); Familial amyloidotic polyneuropathy (FAP); Peripheral nerve; Dorsal root ganglia (DRG); Schwann cell
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Funding
- Kawasaki Medical School [20-104N, 21-114]
- Grants-in-Aid for Scientific Research [21591101] Funding Source: KAKEN
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Transthyretin (TTR) is mainly expressed in the liver and choroid plexus of the brain. The majority of familial amyloidotic polyneuropathy cases are caused by a mutant TTR gene. The origin of the TTR deposited in the peripheral nervous system is unknown. We studied the expression of TTR in the peripheral nerves of normal mice and transgenics bearing the human mutant TTR in a mouse Ttr-null background. Using RT-PCR, Ttr and TTR mRNA was observed in both dorsal root ganglia and sciatic nerves. Ttr mRNA was detected in cultured mouse Schwann cells and the immortalized mouse Schwann cell line, IMS32 cells. Human TTR mRNA and protein were detected in cultured Schwann cells derived from the transgenic mice. We conclude that the TTR gene is expressed in the Schwann cells of peripheral nerves. (C) 2010 Elsevier B.V. All rights reserved.
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