Journal
BRAIN RESEARCH
Volume 1293, Issue -, Pages 61-75Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2009.03.038
Keywords
Addiction; Neurobiology; Stress; Corticotropin-releasing factor; Norepinephrine; Extended amygdala
Categories
Funding
- National Institute on Alcohol Abuse and Alcoholism, Pearson Center for Alcoholism and Addiction Research and National Institutes of Health [AA06420, AA08459]
- National Institute on Drug Abuse, Pearson Center for Alcoholism and Addiction Research and National Institutes of Health [DA04043, DA04398]
- National Institute of Diabetes and Digestive and Kidney Diseases, Pearson Center for Alcoholism and Addiction Research and National Institutes of Health [DK26741]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK026741] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA008459, R37AA008459, P50AA006420, P60AA006420] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA004398, R01DA004043] Funding Source: NIH RePORTER
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Dysregulation of the brain emotional systems that mediate arousal and stress is a key component of the pathophysiology of drug addiction. Drug addiction is a chronically relapsing disorder characterized by a compulsion to seek and take drugs and the development of dependence and manifestation of a negative emotional state when the drug is removed. Activation of brain stress systems is hypothesized to be a key element of the negative emotional state produced by dependence that drives drug-seeking through negative reinforcement mechanisms. The focus of the present review is on the role of two key brain arousal/stress systems in the development of dependence. Emphasis is placed on the neuropharmacological actions of corticotropin-releasing factor (CRF) and norepinephrine in extrahypothalamic systems in the extended amygdala, including the central nucleus of the amygdala, bed nucleus of the stria terminalis, and a transition area in the shell of the nucleus accumbens. Compelling evidence argues that these brain stress systems, a heretofore largely neglected component of dependence and addiction, play a key role in engaging the transition to dependence and maintaining dependence once it is initiated. Understanding the role of the brain stress and anti-stress systems in addiction not only provides insight into the neurobiology of the dark side of addiction but also provides insight into the organization and function of basic brain emotional circuitry that guides motivated behavior. (C) 2009 Elsevier B.V. All rights reserved
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