Journal
BRAIN RESEARCH
Volume 1292, Issue -, Pages 93-99Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2009.07.066
Keywords
Transgenic model; Alzheimer's disease; Aging; Spatial learning; Perseverative tendency; Memory; Passive avoidance; Nesting behavior
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Funding
- Canadian Institutes of Health Research (CIHR)
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A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6 months, appealing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
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