Journal
ANALYTICAL CHEMISTRY
Volume 87, Issue 11, Pages 5614-5619Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b00601
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Funding
- European Research Council [320694]
- European Commission [304886]
- Austrian Science Fund (FWF) [W1210-3]
- Swiss National Science Foundation
- Swiss Nanoscience Institute
- Austrian Science Fund (FWF) [W1210] Funding Source: Austrian Science Fund (FWF)
- European Research Council (ERC) [320694] Funding Source: European Research Council (ERC)
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Laser-induced acoustic desorption (LIAD) has recently been established as a tool for analytical chemistry. It is capable of launching intact, neutral, or low charged molecules into a high vacuum environment. This makes it ideally suited to mass spectrometry. LIAD can be used with fragile biomolecules and very massive compounds alike. Here, we apply LIAD time-of-flight mass spectrometry (TOF-MS) to the natural biochromophores chlorophyll, hemin, bilirubin, and biliverdin and to high mass fluoroalkyl-functionalized porphyrins. We characterize the variation in the molecular fragmentation patterns as a function of the desorption and the VUV postionization laser intensity. We find that LIAD can produce molecular beams an order of magnitude slower than matrix-assisted laser desorption (MALD), although this depends on the substrate material. Using titanium foils we observe a most probable velocity of 20 m/s for functionalized molecules with a mass m = 10 000 Da.
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