Journal
BRAIN RESEARCH
Volume 1258, Issue -, Pages 53-58Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.12.056
Keywords
Adenosine A(1) receptor; Receptor autoradiography; [3H]CPFPX; Sleep deprivation; Sleep homeostasis; Rat
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Funding
- Department of Veterans Affairs Medical Research Service Award
- National Institute of Mental Health [NIMH39683]
- Heinrich Hertz Foundation of the Ministry of Science and Technology
- German Federal Ministry of Education and Research
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Adenosine, increasing after sleep deprivation and acting via the A, adenosine receptor (AIAR), is likely a key factor in the homeostatic control of sleep. This study examines the impact of sleep deprivation on AIAR density in different parts of the rat brain with [H-3]CPFPX autoradiography. Binding of [H-3]CPFPX was significantly increased in parietal cortex (PAR) (7%), thalamus (11%) and caudate-putamen (9%) after 24 h of sleep deprivation compared to a control group with an undisturbed circadian sleep-wake rhythm. Sleep deprivation of 12 h changed receptor density regionally between -5% and +9% (motor cortex (M-1), statistically significant) compared to the circadian control group. These results suggest cerebral A(1)ARs are involved in effects of sleep deprivation and the regulation of sleep. The increase of A(1)AR density could serve the purpose of not only maintaining the responsiveness to increased adenosine levels but also amplifying the effect of sleep deprivation and is in line with a sleep-induced homoeostatic reorganization at the synaptic level. (C) 2008 Elsevier B.V. All rights reserved.
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