Journal
BRAIN RESEARCH
Volume 1249, Issue -, Pages 34-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.10.036
Keywords
Blood-brain barrier; Cholesterol; Glial cell; Endothelial cell; ATP-binding cassette receptors; LDL receptors
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Funding
- foundation Coeur et Arteres
- Ministere de la Recherche
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Brain is the most cholesterol rich organ of the whole body and recent studies suggest a role for the blood-brain barrier (BBB) in cerebral cholesterol homeostasis. Low density lipoprotein receptor (LDLR)-related receptors and ATP-binding Cassette (ABC) transporters play an important role in peripheral sterol homeostasis. The purpose of this study was to determine the mRNA expression profiles of ABC transporters (ABCA1, 2,3,7 and ABCG1) and low density lipoprotein receptor (LDLR)-related receptors (LDLR, vLDLR, LRP1, LRP2 and LRP8) in BBB endothelium using an in vitro co-culture model of bovine brain capillary endothelial cells (BCECs) and rat glial cells. All transcripts tested are expressed by BCECs and in capillary extract, except vLDLR. Glial cells influence ABCG1, A1, 2,7 and LRP1 transcription, suggesting a role in cerebral lipid supply/elimination through the modulation of the expression of these transporters and receptors by these cells. Altogether, these results highlight the importance of glial input in the BBB transport phenotype for sterol homeostasis in the central nervous system, and confirm the importance of the BBB in this process. (C) 2008 Elsevier B.V. All rights reserved.
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