Journal
BRAIN RESEARCH
Volume 1277, Issue -, Pages 115-129Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2009.02.050
Keywords
Development; Synaptogenesis; Comparative; Auditory; Visual; Olfactory
Categories
Funding
- NCRR NIH HHS [P20 RR015574, P20 RR015574-09, P20 RR15574] Funding Source: Medline
- NEI NIH HHS [R01 EY012152-08, R01 EY012152] Funding Source: Medline
- NIDCD NIH HHS [R01 DC007695-02, F32 DC008730, R01 DC007695] Funding Source: Medline
Ask authors/readers for more resources
The development of peripheral to central neural connections within the auditory, visual, and olfactory systems of mice is reviewed to address whether peripheral signaling may play an instructive role during initial synapse formation. For each sensory system, developmental times of histogenesis and the earliest ages of innervation and function are considered for peripheral and selected central relays. For the auditory and visual system, anatomical and functional reports indicate that central connections may form prior to synapse formation in the periphery. However, evidence from the olfactory system suggests that the peripheral olfactory sensory neurons form synaptic connections before more central olfactory connections are established. We find that significant gaps in knowledge exist for embryonic development of these systems in mice and that genetic tools have not yet been systematically directed to address these issues. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available