Journal
JOURNAL OF COGNITIVE NEUROSCIENCE
Volume 27, Issue 10, Pages 2019-2034Publisher
MIT PRESS
DOI: 10.1162/jocn_a_00838
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Funding
- Wellcome Trust
- MRC [MR/J009024/1]
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre based at Oxford University Hospitals Trust Oxford University
- MRC UK MEG [MR/K005464/1]
- MRC [MR/K005464/1, MR/J009024/1] Funding Source: UKRI
- Medical Research Council [MR/J009024/1, MR/K005464/1] Funding Source: researchfish
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We used magnetoencephalography to characterize the spatio-temporal dynamics of cortical activity during top-down control of working memory (WM). fMRI studies have previously implicated both the frontoparietal and cingulo-opercular networks in control over WM, but their respective contributions are unclear. In our task, spatial cues indicating the relevant item in a WM array occurred either before the memory array or during the maintenance period, providing a direct comparison between prospective and retrospective control of WM. We found that in both cases a frontoparietal network activated following the cue, but following retro-cues this activation was transient and was succeeded by a cingulo-opercular network activation. We also characterized the time course of top-down modulation of alpha activity in visual/parietal cortex. This modulation was transient following retrocues, occurring in parallel with the frontoparietal network activation. We suggest that the frontoparietal network is responsible for top-down modulation of activity in sensory cortex during both preparatory attention and orienting within memory. In contrast, the cingulo-opercular network plays a more downstream role in cognitive control, perhaps associated with output gating of memory.
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