Journal
BRAIN RESEARCH
Volume 1235, Issue -, Pages 143-152Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2008.06.114
Keywords
Schizophrenia; Oscillatory networks; Sensory processing; Target; Detection; Intertrial phase coherence (ITC)
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Funding
- FAZIT-Stiftung, Germany
- University of Bremen, Germany [11/854/05]
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In the present study we used a simple visual evoked potential and a visual oddball paradigm to investigate alterations in the temporal integration of different frequency components such as alpha and theta oscillations in patients with schizophrenia. We found that neither the amplitude enhancement after stimulus onset nor the intertrial phase coherence was generally reduced in patients, but that the topography of the neural response was altered. While healthy controls elicited their maximum early alpha as well as late theta response over posterior electrode sites, the maximum response in patients was shifted to anterior electrode positions. This result was not found for the late theta response for targets as target processing was accompanied with frontal theta amplitude enhancement in healthy controls as well. The change of the topographical response pattern was mirrored by the inter-trial phase coherence in both frequency bands. The findings imply that schizophrenia is related to multiple alterations in oscillatory networks. Even during simple tasks without high cognitive demands dysfunctional mechanisms of temporal and regional coordination appear to be of importance in schizophrenia. (c) 2008 Elsevier B.V. All rights reserved.
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