Journal
BRAIN RESEARCH
Volume 1200, Issue -, Pages 27-38Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2008.01.038
Keywords
allodynia; melatonin; depression; anterior cingular cortex; neuropathic pain; nerve injury; WKY rat
Categories
Funding
- NIDCR NIH HHS [R01 DE018538-01, R01 DE018538, R01 DE18538] Funding Source: Medline
- NINDS NIH HHS [R01 NS045681, R01 NS042661, R01 NS045681-04, R01 NS45681, R01 NS042661-04] Funding Source: Medline
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Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melatoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression. (c) 2008 Elsevier B.V. All rights reserved.
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