Journal
BRAIN RESEARCH
Volume 1210, Issue -, Pages 20-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.02.094
Keywords
hair cell; cochlear amplification; glucose transporter; prestin; electromotility; knockout mice
Categories
Funding
- NCI NIH HHS [P30 CA021765, P30 CA021765-29, CA21765] Funding Source: Medline
- NCRR NIH HHS [UL1 RR025741] Funding Source: Medline
- NIDCD NIH HHS [R01 DC006471-05, R01 DC000089-38, R01 DC006471, R01 DC006412-03, R01 DC000089, R21 DC005168-03, DC008800, R01 DC006412, R01 DC004696-08, R21 DC005168, DC004696, DC00089, R21 DC008800-02, DC05168, DC06471, R01 DC004696, R21 DC008800, DC006412] Funding Source: Medline
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Glucose transporter 5 (Glut5) is a high-affinity fructose transporter. It was proposed to be a motor protein or part of the motor complex required for cochlear amplification in outer hair cells (OHCs). Here we show that, in contrast to previous reports, Glut5 is undetectable, and possibly absent, in OHCs harvested from wildtype mice. Further, Glut5-deficient mice display normal OHC morphology and motor function (i.e., nonlinear capacitance and electromotility) and normal cochlear sensitivity and frequency selectivity. We conclude that Glut5 is not required for OHC motility or cochlear amplification. (C) 2008 Elsevier B.V. All rights reserved.
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