Journal
BRAIN RESEARCH
Volume 1244, Issue -, Pages 71-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2008.09.076
Keywords
Lateral hypothalamus; Motor trigeminal nucleus; Parvicellular reticular formation; Jaw movement; Rat
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Funding
- Ministry of Education, Science, Sports and Culture of Japan [19500294]
- Grants-in-Aid for Scientific Research [19500294] Funding Source: KAKEN
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This study was performed to. understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labeled neurons were found in the posterior lateral hypothalamus (PLH) bilaterally with a clear-cut ipsilateral dominance. After ipsilateral injections of biotinylated dextran amine (BDA) into the PLH and CTb into the motor trigeminal nucleus (Vm), the prominent distribution of BDA-labeled axon terminals around CTb-labeled neurons was found-in the RFp region just ventral to the nucleus of the solitary tract and medial to the spinal trigeminal nucleus ipsilateral to the injection sites. Within the neuropil of the RFp, BDA-labeled axon terminals made an asymmetrical synaptic contact predominantly with-dendrites, and additionally with somata of the RFp neurons, some of which were labeled with CTb. It was further revealed that these BDA-labeled axon terminals were immunoreactive for vesicular glutamate transporter 2. The present data suggest that the PLH plays an important role in the control of jaw movements by exerting its glutamatergic excitatory action upon RFp neurons presynaptic to trigeminal motoneurons. (C) 2008 Elsevier B.V. All rights reserved.
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