Journal
BRAIN PATHOLOGY
Volume 23, Issue 2, Pages 206-209Publisher
WILEY
DOI: 10.1111/bpa.12020
Keywords
DNA methylation; ependymoma; epigenetic therapy; epigenetics
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Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic profile. Candidate gene approaches looking at hypermethylated promoters and genome-wide epigenetic arrays suggest that DNA methylation may be critical to ependymoma pathogenesis. This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients.
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